Alibaba.com offers 101 diethylene glycol monobutyl ether products. Reference: 1. All structured data from the main, Property, Lexeme, and EntitySchema namespaces is available under the. What is Diethylene Glycol Monobutyl Ether? DEG is a widely used solvent. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. This page was last edited on 28 November 2020, at 22:06. 14th ed. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. 3053. [55][56] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. [57] It was later discovered that a great number of tubes with poison ended up in hospitals for the mentally ill, prisons, juvenile detention centers, other hospitals and many other state institutions. Diethylene Glycol Monobutyl Ether exposure symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether exposure (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. 17 November 2016. Internal Medicine Residency Program of the College of Medicine of Wake Forest University, North Caroline, U.S.A. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Once he was inside, there was nothing to do: the plant had already been shut down. Barewa Pharmaceuticals was shut down and the product was pulled off the shelves. [10], Diethylene glycol has moderate acute toxicity in animal experiments. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. of morpholine and 1,4-dioxane. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. In November, The New York Times published a wine recall that the Federal Government released after the Bureau of Alcohol, Tobacco and Firearms tested 1,000 bottles. [1][7], At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. Notice of Adoption to Text of Regulations Title 22, Amendment to Section 12805 Maximum Allowable Dose Levels (MADLs) for Ethylene Glycol Monoethyl Ether (EGEE), Ethylene Glycol Monoethyl Ether Acetate (EGEEA), and Potassium Dimethyldithiocarbamate A wide variety of diethylene glycol monobutyl ether options are available to you, such as classification, grade standard, and usage. Authorities warn against using some toothpastes, Taste of Raspberries, Taste of Death – The 1937 Elixir Sulfanilamide Incident, "Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities", "Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination", "Popular Wines found to hold toxic chemical. [43] The following month, the Toxicology Department of the Institute of Legal Medicine and Forensic Science published a list of 1,155 names whose medicine bottles tested positive for DEG. [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. Seventeen other persons have also been charged related to this incident. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". [1] In personal care products (e.g. BACKGROUND A risk assessment of DEGBE with the chemical name 2-(2-butoxyethoxy)ethanol or diethylene glycol monobutyl ether was done by a member state (France). 2 Pharmaceutical in 2005. Fourteen patients received hemodialysis, but the treatment failed. [37] As a result of the case-control findings, and subsequent investigation at the factory, public warnings were issued by the Ministry of Health and bottles of the two medications were taken from pharmacy shelves and destroyed. Incidents include its use in China as a component of cheap toothpaste, and by winemakers in Europe as an adulterant to create a "sweet" wine. Diethylene glycol monobutyl ether is used as a solvent in paints and varnishes e.g. Laboratory testing at CDC of samples taken from parents revealed significant contamination with DEG. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 9: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. [29], When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. AICS Chemical ID. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. Postmortem examination revealed damage in the kidneys and liver, and laboratory testing found DEG instead of propylene glycol in the sedatives. Between November 1995 and June 1996, almost 109 children admitted to the University Hospital in Port-au-Prince, Haiti, presented with acute kidney failure. It is also used in printing inks when very slow drying is desired. The Himachal Pradesh government is filing a criminal case against the company and its executives. High boiling point. As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical is versatile solvent of product obtains by reaction betweeen ethylene oxide and n-Butanol. The industry generally operates to maximize MEG production. [26] The next year, an Austrian electric power plant (Österreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[38]. Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. "Counterfeit Colgate Toothpaste Found", June 14, 2007. CARBITOL Solvent. [31], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. Nearly half of the victims were under the age of two. diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO 2. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. After manufacturing a second batch of syrup containing diethylene glycol for Qiquhar Pharmaceutical, no taste-test was performed. [35] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[36][29][37]. The ether being relatively unreactive. U.S. Food and Drug Administration Press Release. [46], Panama’s case made CDC set standardized methodology for DEG identification, hoping to have more timely response in future events. Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. in textile processing and serves as an intermediary product in the chemical industry. Bureau of Alcohol, Tobacco, and Firearms. Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. [14][15], In 1937, S.E. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. [49][50][51] For the end of the month, the Chinese government committed to investigate the “supposedly” tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. stated in. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements."[4]. This product is created when ethylene oxide and n-butanol are combined. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. Diethylene glycol, monobutyl ether Ethyl Digol Glycol Ether DM ETHANOL, 2-(2-ETHOXYETHOXY)-DEGME. ", "Scandal over poisoned wine embitters village in Austria.". Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. English: Structure of Diethylene glycol monobutyl ether acetate. 17 November 2016. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. They identified Tianhong Fine Chemicals Factory as the manufacturer. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. It is a clear liquid with a very low odor and high boiling point. In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. CS1 maint: multiple names: authors list (. Some time later, Wang found a reference to diethylene glycol in a chemical book. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. [3] Depending on the conditions, varying amounts of DEG and related glycols are produced. [59] Soon, other countries also recalling Chinese-made toothpaste were Belize, Canada, Mozambique, Saudi Arabia, New Zealand, Spain, Italy, Japan, and Ireland, plus an Indianapolis, Indiana US hotel-supplier that distributed Chinese toothpaste in Barbados, Belgium, Bermuda, Britain, Canada, Dominican Republic, France, Germany, Ireland, Italy, Mexico, Spain, Switzerland, Turks and Caicos, the United Arab Emirates and United States. While the FDA tried to find out Tianhong’s address, Chinese officials were reluctant to become involved. Patients who survive but develop kidney failure remain dialysis-dependent. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. Jump to: navigation, search. Dermal absorption is very low, unless it is administered on broken or damaged skin. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. [3], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. [5] DEG is used as a building block in organic synthesis, e.g. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[1] and others suggest this is the LD30. Butyl di glycol (also known as BDG, butyl dioxitol, diethylene glycol monobutyl ether, 2(-2butoxyethoxy) ethanol and butoxydiethylene glycol) is a colourless, clear organic compound with a faint characteristic odour that has the formula C 8 H 18 O 3.It is soluble in water and miscible with many common solvents, and also has low volatility and a high boiling point. [39] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPhI worldwide (the world’s largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. [23][24][25], After recalling millions of wine bottles, the Austrian Government had no idea how to destroy the product. All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. Promotes uniform dispersion; translucent to clear. "Austrian power plant to burn 'bad' wine. Low vapor pressure. The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. [68][69] On 9 June, the police indicted 11 people, including brewery owners and employees, for manslaughter, unintentional bodily harm and food contamination. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. The toothpaste was labeled as “Manufactured in South Africa” and contained misspellings like "isclinically", "SOUTH AFRLCA" and "South African Dental Assoxiation". Reuter. They react with oxoacids and carboxylic acids to … OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 4 1. O’Neil M. The Merck Index. Diethylene Glycol Ether Factory Offer High Grade 99% Butyldiglycol/ Diethylene Glycol Monobutyl Ether Cas 112-34-5 US $2.00-$5.00 / Kilogram 1.0 Kilograms (Min Order) This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. Wang declared that after making the first order of counterfeit syrup, he swallowed some of it. U.S. Food and Drug Administration Press Release. CAS Number 111-76-2 Synonym(s) EGBE, AI-0993; Bucs; Butoxyethanol; Beta-butoxyethanol; 2-Butoxyethanol; 2-butoxy-1-ethanol; Butyl cellosolve; o-butyl ethylene glycol; Butyl glycol; Butyl oxitol; Caswell No. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. Details : Ethylene Glycol Monobutyl Ether. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. [58], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. [1][7], Based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular filtration. Wang Guiping discovered how easy it was to enter China’s pharmaceutical supply business and earn extra money. Date: 27 January 2011: Source: Own work: Author: MiPe: Licensing . [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Whitehouse Station, NJ: Merck & Co; 2006. 2-(2-Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to … When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. [38], Ending June 1996, the FDA had discovered counterfeit glycerin traced back to Chemical Trading and Consulting (a German broker), which bought 72 barrels of the syrup from Vos B.V., a Dutch company. The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). Furthermore, it is also found in domestic detergents and brewing chemicals. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. 86-13. [61], Ending November 2008, infants started to die after developing unexplained fevers and vomiting. Diethylene glycol monobutyl ether. Further investigation revealed all patients were treated with topical silver sulfadiazine ointment that contained 7 g/kg of DEG. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. 9TB90IYC0E. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. [20], In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. Investigations revealed that all had taken a medicine called “My Pikin Baby”, a teething mixture tainted with diethylene glycol. title. It appears diethylene glycol is more hazardous to humans than implied by oral toxicity data in laboratory animals.[1]. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. 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